The effects of diethylstilboesterol and castration on the nucleic acid and protein metabolism of rat prostate gland
FR Mangan, GE Neal, DC Williams - Biochemical Journal, 1967 - ncbi.nlm.nih.gov
FR Mangan, GE Neal, DC Williams
Biochemical Journal, 1967•ncbi.nlm.nih.govImplantation of diethylstilboestrol pellets into adult male rats brings about similar
biochemical changes in the nucleic acid and protein metabolism to castration. 2. The avidity
of the prostate for labelled diethylstilboestrol was greater than that of the other organs
examined. 3. Uptake of labelled diethylstilboestrol and testosterone into the nuclei of the rat
prostate is greater in castrated rats than in controls. 4. Diethylstilboestrol appeared to be
associated with the protein and not with the DNA fraction of the nucleus.
biochemical changes in the nucleic acid and protein metabolism to castration. 2. The avidity
of the prostate for labelled diethylstilboestrol was greater than that of the other organs
examined. 3. Uptake of labelled diethylstilboestrol and testosterone into the nuclei of the rat
prostate is greater in castrated rats than in controls. 4. Diethylstilboestrol appeared to be
associated with the protein and not with the DNA fraction of the nucleus.
Abstract
1. Implantation of diethylstilboestrol pellets into adult male rats brings about similar biochemical changes in the nucleic acid and protein metabolism to castration. 2. The avidity of the prostate for labelled diethylstilboestrol was greater than that of the other organs examined. 3. Uptake of labelled diethylstilboestrol and testosterone into the nuclei of the rat prostate is greater in castrated rats than in controls. 4. Diethylstilboestrol appeared to be associated with the protein and not with the DNA fraction of the nucleus.
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