The central nervous sytem-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS)
JF Kaye, NK de Rosbo, I Mendel, S Flechter… - Journal of …, 2000 - Elsevier
Uncovering primary target antigens in multiple sclerosis (MS) is of major significance for
understanding the etiology and pathophysiology of the disease, and for designing
immunospecific therapy. In this study, a synthetic peptide representing a predicted T cell
epitope on myelin oligodendrocytic basic protein (MOBP) was found to be encephalitogenic
in C3H. SW mice, inducing experimental autoimmune encephalomyelitis with an abrupt
onset. Two separate preliminary studies with MOBP peptides indicated that autoreactivity to …
understanding the etiology and pathophysiology of the disease, and for designing
immunospecific therapy. In this study, a synthetic peptide representing a predicted T cell
epitope on myelin oligodendrocytic basic protein (MOBP) was found to be encephalitogenic
in C3H. SW mice, inducing experimental autoimmune encephalomyelitis with an abrupt
onset. Two separate preliminary studies with MOBP peptides indicated that autoreactivity to …