The level of 7-dehydrocholesterol in plasma reflects the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the human liver
M Axelson, B Angelin, CG Hillebrant, E Reihnér… - … et Biophysica Acta (BBA …, 1998 - Elsevier
Plasma levels of the cholesterol precursor 7-dehydrocholesterol (7-DHC) were compared
with activities of the rate-limiting enzyme in cholesterol biosynthesis, 3-hydroxy-3-
methylglutaryl coenzyme A (HMG-CoA) reductase assayed in liver biopsies from patients
undergoing cholecystectomy. Some patients were treated with cholestyramine, deoxycholic
acid or chenodeoxycholic acid prior to surgery in order to alter the activity of the enzyme.
The median level of 7-DHC and the activity of HMG-CoA reductase in the untreated group …
with activities of the rate-limiting enzyme in cholesterol biosynthesis, 3-hydroxy-3-
methylglutaryl coenzyme A (HMG-CoA) reductase assayed in liver biopsies from patients
undergoing cholecystectomy. Some patients were treated with cholestyramine, deoxycholic
acid or chenodeoxycholic acid prior to surgery in order to alter the activity of the enzyme.
The median level of 7-DHC and the activity of HMG-CoA reductase in the untreated group …