Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens
JP Kane, MJ Malloy, TA Ports, NR Phillips, JC Diehl… - Jama, 1990 - jamanetwork.com
We conducted a randomized, controlled trial in 72 patients with heterozygous familial
hypercholesterolemia to test whether reducing plasma low-density lipoprotein levels by diet
and combined drug regimens can induce regression of coronary lesions. Four hundred fifty-
seven lesions were measured before and after a 26-month interval by computer-based
quantitative angiography. The primary outcome variable was within-patient mean change in
percent area stenosis. Mean low-density lipoprotein cholesterol levels decreased from …
hypercholesterolemia to test whether reducing plasma low-density lipoprotein levels by diet
and combined drug regimens can induce regression of coronary lesions. Four hundred fifty-
seven lesions were measured before and after a 26-month interval by computer-based
quantitative angiography. The primary outcome variable was within-patient mean change in
percent area stenosis. Mean low-density lipoprotein cholesterol levels decreased from …