[HTML][HTML] Manipulation of TGF-β to control autoimmune and chronic inflammatory diseases
W Chen, SM Wahl - Microbes and infection, 1999 - Elsevier
Defining the mechanisms whereby transforming growth factor-beta (TGF-β) controls
physiologic inflammation and the immune response and how it contributes to pathology
when it is dysregulated is critical to our ability to manipulate the levels and activity of this
potent cytokine for therapeutic benefit. In keeping with its dichotomous nature, recent
evidence suggests that overproduction and/or activation contribute to persistent
inflammation and that antagonists of TGF-β delivered locally can break the cycle of …
physiologic inflammation and the immune response and how it contributes to pathology
when it is dysregulated is critical to our ability to manipulate the levels and activity of this
potent cytokine for therapeutic benefit. In keeping with its dichotomous nature, recent
evidence suggests that overproduction and/or activation contribute to persistent
inflammation and that antagonists of TGF-β delivered locally can break the cycle of …