DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS …
SA Banerjee, S Roffler-Tarlov, M Szabo… - Molecular brain …, 1994 - Elsevier
Abstract Transgenic mice bearing 4.8 kilobases (kb) of upstream rat tyrosine hydroxylase
(TH) sequences linked to a human growth hormone gene (hGH) exhibited cell-specific
expression of hGH in all the appropriate catecholaminergic neurons in the central nervous
system (CNS), although with different penetrance in two different mouse lineages. No
ectopic expression was observed in any brain or peripheral region in one founder and its
progeny. In another founder there was some ectopic expression in addition to appropriate …
(TH) sequences linked to a human growth hormone gene (hGH) exhibited cell-specific
expression of hGH in all the appropriate catecholaminergic neurons in the central nervous
system (CNS), although with different penetrance in two different mouse lineages. No
ectopic expression was observed in any brain or peripheral region in one founder and its
progeny. In another founder there was some ectopic expression in addition to appropriate …