p-Hydroxyphenylacetaldehyde is the major product of L-tyrosine oxidation by activated human phagocytes: a chloride-dependent mechanism for the conversion of …
Reactive aldehydes generated during lipid peroxidation have been implicated in the
pathogenesis of atherosclerosis as well as other inflammatory diseases. A potential catalyst
for such reactions is myeloperoxidase, a hemeprotein secreted by activated phagocytes. We
now report that activated neutrophils utilize the myeloperoxidase-H 2 O 2-chloride system to
convert L-tyrosine to p-hydroxyphenylacetaldehyde. Production of p-
hydroxyphenylacetaldehyde was nearly quantitative at physiological concentrations of L …
pathogenesis of atherosclerosis as well as other inflammatory diseases. A potential catalyst
for such reactions is myeloperoxidase, a hemeprotein secreted by activated phagocytes. We
now report that activated neutrophils utilize the myeloperoxidase-H 2 O 2-chloride system to
convert L-tyrosine to p-hydroxyphenylacetaldehyde. Production of p-
hydroxyphenylacetaldehyde was nearly quantitative at physiological concentrations of L …
