[HTML][HTML] Regulation of Vascular Smooth Muscle Growth by α1-Adrenoreceptor Subtypes in Vitro and in Situ (∗)
LQ Chen, X Xin, AD Eckhart, N Yang… - Journal of Biological …, 1995 - ASBMB
Rat aorta smooth muscle cells which express all three α 1-adrenoreceptors (α 1A, α 1B and
α 1D) were used to determine the effect of stimulation of α 1-adrenergic receptor subtypes
on cell growth." Combined" α 1-adrenoreceptor subtype stimulation with norepinephrine
alone caused a concentration-dependent, prazosin-sensitive increase in protein content and
synthesis: 48 h of stimulation at 1 μM increased cell protein to 216±40% of time-matched
controls (p= 0.008) and RNA to 140±13%(p= 0.03); protein synthesis increased to …
α 1D) were used to determine the effect of stimulation of α 1-adrenergic receptor subtypes
on cell growth." Combined" α 1-adrenoreceptor subtype stimulation with norepinephrine
alone caused a concentration-dependent, prazosin-sensitive increase in protein content and
synthesis: 48 h of stimulation at 1 μM increased cell protein to 216±40% of time-matched
controls (p= 0.008) and RNA to 140±13%(p= 0.03); protein synthesis increased to …