Role of poly-(ADP-ribose) synthetase in lipopolysaccharide-induced vascular failure and acute lung injury in pigs
M Albertini, MG Clement, CL Lafortuna, M Caniatti… - Journal of critical …, 2000 - Elsevier
Purpose: To assess the contribution of poly (adenosine 5′-diphosphate ribose) synthetase
(PARS) to the development of bacterial lipopolysaccharide (LPS)-induced acute lung injury
and vascular failure in pigs. Materials and Methods: Four groups of anesthetized, paralyzed,
and mechanically ventilated domestic white pigs. Group 1 served as control, whereas
Escherichia coli LPS (20 μg/kg/h) was continuously infused in group 2. Group 3 received 20
mg/kg injection of 3-aminobenzamide (a selective inhibitor of PARS activity) 15 minutes …
(PARS) to the development of bacterial lipopolysaccharide (LPS)-induced acute lung injury
and vascular failure in pigs. Materials and Methods: Four groups of anesthetized, paralyzed,
and mechanically ventilated domestic white pigs. Group 1 served as control, whereas
Escherichia coli LPS (20 μg/kg/h) was continuously infused in group 2. Group 3 received 20
mg/kg injection of 3-aminobenzamide (a selective inhibitor of PARS activity) 15 minutes …
