Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5
S An, Y Zheng, T Bleu - Journal of Biological Chemistry, 2000 - ASBMB
Sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite
retraction. Contradictory reports propose that S1P acts as either an intracellular second
messenger or an extracellular ligand for cell-surface receptors. Hence, the precise signaling
mechanisms mediating the diverse cellular effects of S1P remain to be determined. Here, we
investigate whether S1P stimulation of cell proliferation, survival, and related signaling
events can be mediated by the recently cloned Edg family members of G protein-coupled …
retraction. Contradictory reports propose that S1P acts as either an intracellular second
messenger or an extracellular ligand for cell-surface receptors. Hence, the precise signaling
mechanisms mediating the diverse cellular effects of S1P remain to be determined. Here, we
investigate whether S1P stimulation of cell proliferation, survival, and related signaling
events can be mediated by the recently cloned Edg family members of G protein-coupled …