[HTML][HTML] Opposite regulation of transepithelial electrical resistance and paracellular permeability by Rho in Madin-Darby canine kidney cells
Small GTPase Rho has been thought to be important for the formation and the maintenance
of tight junction in epithelial cells, but the role of Rho in the regulation of barrier function of
tight junction is not well understood. We here examined whether Rho was involved in the
barrier function of tight junction in Madin-Darby canine kidney (MDCK) cells. The activation
of prostaglandin EP3β receptor, coupled to a Rho activation pathway, induced the increase
in transepithelial electrical resistance (TER) but the increase in paracellular flux of mannitol …
of tight junction in epithelial cells, but the role of Rho in the regulation of barrier function of
tight junction is not well understood. We here examined whether Rho was involved in the
barrier function of tight junction in Madin-Darby canine kidney (MDCK) cells. The activation
of prostaglandin EP3β receptor, coupled to a Rho activation pathway, induced the increase
in transepithelial electrical resistance (TER) but the increase in paracellular flux of mannitol …