Suppression of immune responses to acetylcholine receptor by interleukin 2-fusion toxin: in vivo and in vitro studies
LJ Balcer, KR McIntosh, JC Nichols… - Journal of …, 1991 - Elsevier
The pathogenesis of the autoimmune disease, myasthenia gravis (MG), involves an
antibody-mediated attack against acetylcholine receptors (AChRs). Since the relevant
antibody response is T cell dependent, a therapeutic strategy aimed at T lymphocytes
actively participating in the immune reaction to AChR should result in relatively selective
suppression of AChR antibody. During an active immune response, T cells express
receptors for interleukin 2 (IL2). In this study, we have used a genetically engineered fusion …
antibody-mediated attack against acetylcholine receptors (AChRs). Since the relevant
antibody response is T cell dependent, a therapeutic strategy aimed at T lymphocytes
actively participating in the immune reaction to AChR should result in relatively selective
suppression of AChR antibody. During an active immune response, T cells express
receptors for interleukin 2 (IL2). In this study, we have used a genetically engineered fusion …
