Suppression of murine experimental autoimmune thyroiditis by oral administration of porcine thyroglobulin
KE Peterson, H Braley-Mullen - Cellular immunology, 1995 - Elsevier
Experimental autoimmune thyroiditis (EAT) induced by the transfer of mouse thyroglobulin
(MTg)-immunized spleen cells, activatedin vitrowith MTg, can be suppressed by oral
administration of PTg to donor mice prior to immunization. Oral administration of 1 mg PTg
five times over a 10-day period before immunization with MTg-LPS resulted in reduced EAT
severity in recipient mice compared with recipients of cells from saline-fed immunized
donors. MTg-or PTg-specific proliferative responses were not decreased in PTg-fed donors …
(MTg)-immunized spleen cells, activatedin vitrowith MTg, can be suppressed by oral
administration of PTg to donor mice prior to immunization. Oral administration of 1 mg PTg
five times over a 10-day period before immunization with MTg-LPS resulted in reduced EAT
severity in recipient mice compared with recipients of cells from saline-fed immunized
donors. MTg-or PTg-specific proliferative responses were not decreased in PTg-fed donors …
