Ligand-dependent Antagonism by Retinoid X Receptors of Inhibitory Thyroid Hormone Response Elements∗
O Cohen, TR Flynn, FE Wondisford - Journal of Biological Chemistry, 1995 - ASBMB
The role of retinoid X receptors (RXRs) on negative thyroid hormone response elements
(nTREs) is not well understood. In this report, we demonstrate that an orientation-specific
monomeric thyroid hormone receptor (T 3 R) DNA-binding site mediates thyroid hormone
inhibition in the thyrotropin β subunit gene (TSH-β) from human and murine species. Unlike
positive TREs, addition of the ligand 9-cis retinoic acid (9-cis RA) to cells transfected with a T
3 R β1 expression vector significantly reduces thyroid hormone inhibition of the TSH-β gene …
(nTREs) is not well understood. In this report, we demonstrate that an orientation-specific
monomeric thyroid hormone receptor (T 3 R) DNA-binding site mediates thyroid hormone
inhibition in the thyrotropin β subunit gene (TSH-β) from human and murine species. Unlike
positive TREs, addition of the ligand 9-cis retinoic acid (9-cis RA) to cells transfected with a T
3 R β1 expression vector significantly reduces thyroid hormone inhibition of the TSH-β gene …
