Gastrin is a target of the β-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis
J. Clin. Invest. Theodore J. Koh, et al. 106:533 doi:10.1172/JCI9476 [Go to this article.]

Figure 3
Effect of gastrin deficiency on APC^min–/+ mice. (a) Total polyp number in the small intestine and hematocrit from fifteen 6-month-old gastrin-deficient APC^min–/+ mice compared (shaded bars) with fifteen 6-month-old control APC^min–/+ mice (wild-type for the gastrin allele in the same genetic background; filled bars) (^AP < 0.05). (b) The number of small intestinal polyps from the gastrin-deficient (shaded bars) and control APC^min–/+ mice (filled bars) as stratified by size (^AP < 0.05).