Acute modulation of endothelial Akt/PKB activity alters nitric oxide–dependent vasomotor activity in vivo
J. Clin. Invest. Zhengyu Luo, et al. 106:493 doi:10.1172/JCI9419 [
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Figure 4Assessment of blood flow in treated rabbit femoral arteries by Doppler guide wire measurements. Base-line blood flow is increased by endothelial expression of myr-Akt. Increased blood flow resulting from infusion of Ach is attenuated by endothelial expression of dn-Akt, but vessels respond normally to NTG. Data are presented as mean ± SEM. (
n = 5;
AP < 0.05 relative to the same agonist treatment group in saline or Adeno-β-gal–treated vessels.)
