Acute modulation of endothelial Akt/PKB activity alters nitric oxide–dependent vasomotor activity in vivo
J. Clin. Invest. Zhengyu Luo, et al. 106:493 doi:10.1172/JCI9419 [
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Figure 3dn-Akt blocks vasodilation in response to the endothelium-dependent agonist Ach, but vessels respond normally to NTG. Data are expressed as the percentage change in vessel diameter relative to the base-line (untreated) diameter in the mock-infected (saline) group as determined by quantitative angiography. Data are presented as mean ± SEM. (
n = 5;
AP < 0.05 relative to saline-treated, Adeno-β-gal–treated, or Adeno-myr-Akt–treated vessels in the presence of Ach, or all treatment conditions in the presence of NTG.)
