Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory for Blood Cell Research, Amsterdam, Netherlands.
Address correspondence to: Derk Amsen, Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory for Blood Cell Research, Plesmanlaan 125, 1066CX, Amsterdam, Netherlands. Phone: 31.20.512.3976; E-mail: firstname.lastname@example.org.
First published March 20, 2017 - More info
See the related article at Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.
Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only treatment option for several severe hematological malignancies. The development of graft-versus-host disease (GVHD) is a common complication of the procedure and results when donor T cells become activated against recipient-specific antigens. The factors that drive the alloreactive T cell response are not completely understood. In this issue of the
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