Mast cells (MCs) are present in various tissues and are responsible for initiating many of the early inflammatory responses to extrinsic challenges. Recent studies have demonstrated that MCs can tailor their responses, depending on the stimulus encountered and the tissue in which they are stimulated. In this issue of the
Jörn Karhausen, Soman N. Abraham
Differential granule processing after FcεRI engagement versus GPCR engagement.
Mast cells (MCs) launch very specific response programs depending on the nature of the stimulus. In this issue, Gaudenzio and colleagues show that MC degranulation is mediated by at least two distinct pathways. (