Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene
J. Clin. Invest. Jing Jin Gu, et al. 106:599 doi:10.1172/JCI8669 [
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Figure 8Alterations in ATP (closed bars) and GTP (hatched bars) levels in splenocytes of
IMPDH II+/–,
HPRT–/o mice as a function of lymphocyte activation. Values were determined after 48 hours of stimulation with Con A or antibodies, are plotted as the percentage of values obtained from wild-type splenocytes under similar conditions, and represent the mean ± SD from duplicate determinations on five animals.
AP < 0.0027. Nucleotide levels (nmol/10
7 cells) for wild-type resting splenocytes were 2.105 (ATP) and 0.27 (GTP). Levels of GTP were increased by 3.4-fold ± 0.8-fold after Con A stimulation, and by 7.7-fold ± 2.6-fold following Ab stimulation.
