Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene
J. Clin. Invest. Jing Jin Gu, et al. 106:599 doi:10.1172/JCI8669 [
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Figure 7Effect of mutations on the cytolytic activity of cytotoxic T lymphocytes. The function of cytotoxic T lymphocytes from wild-type (open squares) and
IMPDH II+/–,
HPRT–/o (closed squares) mice was analyzed in a
51Cr-release assay. A representative experiment performed in triplicate is shown.
P values were calculated from four experiments performed in triplicate:
P < 0.05 at E:T = 1:1;
P < 0.015 at E:T = 3:1;
P < 0.012 at E:T = 9:1, 27:1, and 50:1.
