Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene
J. Clin. Invest. Jing Jin Gu, et al. 106:599 doi:10.1172/JCI8669 [
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Figure 5Effect of loss of IMPDH II and/or HPRT activities on mouse splenocyte proliferation. Mouse splenocytes were stimulated with Con A (
a), LPS (
b), PMA plus ionomycin (
c), or anti-CD3 plus anti-CD28 (
d) for 24, 48, and 72 hours. Proliferation of T or B cells from wild-type (closed circles),
HPRT–/o (open circles),
IMPDH II+/– (closed triangles), and
IMPDH II+/–,
HPRT–/o (open triangles) mice was measured by
3H-thymidine incorporation.
n = 3 for
HPRT–/o or
IMPDH II+/– mice;
n = 5 for
IMPDH II+/–,
HPRT–/o or wild-type mice. Values are means ± SD.
AP < 0.04;
BP < 0.003.
