Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene
J. Clin. Invest. Jing Jin Gu, et al. 106:599 doi:10.1172/JCI8669 [Go to this article.]

Figure 2
Targeted disruption of the IMPDH type II gene. (a) Restriction map of the wild-type IMPDH type II locus, the knock-out construct, and the expected recombinant allele. Exons are indicated by boxes. The two BglII fragments expected from the wild-type (11 kb) and recombinant (6 kb) alleles are shown, and the probe used for Southern hybridization is indicated. P indicates the PGK promoter. (b) Southern blot showing 11-kb and 6-kb bands in four heterozygous ES clones.