Stroke is one of the leading causes of death and disability worldwide. Stroke recovery is orchestrated by a set of highly interactive processes that involve the neurovascular unit and neural stem cells. Emerging data suggest that exosomes play an important role in intercellular communication by transferring exosomal protein and RNA cargo between source and target cells in the brain. Here, we review these advances and their impact on promoting coupled brain remodeling processes after stroke. The use of exosomes for therapeutic applications in stroke is also highlighted.
Zheng Gang Zhang, Michael Chopp
Potential of exosome-mediated intercellular communication in brain remodeling after stroke.
Exosomes transfer proteins and RNAs to influence neurogenesis, angiogenesis, and oligodendrogenesis. EVs, extracellular vesicles.