Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation
J. Clin. Invest. Bart N. Lambrecht, et al. 106:551 doi:10.1172/JCI8107 [Go to this article.]

Figure 3
Effect of OVA exposure on lung histology in animals immunized with DCs. Mice were treated as in Figure 2. At 24 hours after the last aerosol, lungs were fixed and processed for histological analysis. H&E staining. ×400. (a) Representative section from a mouse immunized with PBS-DC and exposed to PBS aerosol. No abnormalities are noticed. (b and c) Representative sections from mice immunized with OVA-DC and subsequently exposed to OVA-aerosol. These mice develop peribronchial and perivascular eosinophil-rich infiltrates (b) and airway mucosal changes typical of goblet cell hyperplasia (c).