Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation
J. Clin. Invest. Bart N. Lambrecht, et al. 106:551 doi:10.1172/JCI8107 [
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Figure 1(
a) Localization of CFSE
+ DC 36 hours after intratracheal injection of 1 × 10
6 DCs into naive mice. DC were identified in BALF, digested lung tissue, and mediastinal and inguinal LNs as CD3
–B220
– cells of low autofluorescence, strongly expressing CD11c. Injected DCs can be discriminated from endogenous DCs by green fluorescence of CFSE. The percentage of CFSE
+ DCs among all LN cells is indicated. (
b) Kinetics of appearance of CFSE
+ DC in BALF (open squares, left
y axis) and mediastinal LNs (filled squares, right
y axis). Representative of five mice per time point in the group.
