A 38-year-old man with a history of HIV infection virologically suppressed on antiretroviral therapy presents to his gastroenterologist for evaluation of iron deficiency anemia and weight loss. A diagnostic colonoscopy demonstrates a two-centimeter ulcerated mass in the cecum. Biopsies of the lesion return moderately differentiated adenocarcinoma that is wild type for the KRAS mutation by real-time PCR.
Martin J. Wolff, Michael A. Poles, Judith A. Aberg
Endoscopic and histological analysis of the terminal ileum in an HIV-uninfected (
Immunohistological staining for CD4 was performed by sectioning biopsies from ileal lymphoid tissue followed by H&E staining and immunostaining for CD4 (