Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation
J. Clin. Invest. Yassine Sassi, et al. 118:2747 doi:10.1172/JCI35067 [Go to this article.]

Figure 8
MRP4 inhibition enhances CREB phosphorylation. (A) Representative western blot and quantitative evaluation of pCREB in proliferating hCASMCs transfected with MRP4 siRNA or scrambled siRNA (n = 3). (B) Quantitative evaluation of the activity of the cAMP-responsive element CRE measured with the luciferase reporter CRE-Luc in proliferating hCASMCs transfected with scrambled siRNA or MRP4 siRNA (n = 3). **P < 0.01.