Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation
J. Clin. Invest. Yassine Sassi, et al. 118:2747 doi:10.1172/JCI35067 [Go to this article.]

Figure 7
MRP4 inhibition enhances the cAMP effect, but not the cGMP effect, on hCASMC proliferation. Concentration-dependent antiproliferative effect of (A) the activator of cAMP-signaling forskolin or (B) the activator of cGMP-signaling SNP (n = 5 in triplicate) in cells transfected for 72 h with MRP4 siRNA or scrambled siRNA. (C) hCASMC proliferation of cells transfected with MRP4 siRNA or scrambled siRNA in the presence of specific inhibitors of PKA or PKG. The effect of MRP4 inhibition on hCASMC proliferation was reversed in the presence of Ad-PKI but not KT5823 (2 μM, a specific PKG inhibitor) in both cases. n = 3 per group, **P ≤ 0.01.