Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns
J. Clin. Invest. Joshua H. Wong, et al. 118:2969 doi:10.1172/JCI34957 [Go to this article.]

Figure 2
Effect of GH on whole-blood clotting and thrombosis in vivo. Blood was collected and prepared as in Figure 1. (A) Individual whole-blood clotting times. Mean clotting times (lines) were significantly shorter in male (filled squares) versus female (filled circles) lit^m/+ mice; *P < 0.01. Mean clotting times were significantly longer in male (open squares) and female (open circles) GH-deficient lit^m/m mice versus lit^m/+ mice; ***P < 0.001, ANOVA with Bonferroni’s post-hoc test. (B) The indicated number of animals of each sex were injected with 2 μl/g of a 1:80 dilution of thromboplastin in the PE model as in Figure 1. Median survival was greater in female versus male lit^m/+ mice (P = 0.001, log-rank test) and in lit^m/m (dashed lines) animals versus lit^m/+ (solid lines; P = 0.0001, log-rank test): 165, 232, 1,200, and 900 seconds and 0%, 17%, 58%, and 47% in male and female lit^m/+ and lit^m/m mice respectively.