Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
J. Clin. Invest. Maureen A. Su, et al. 118:1712 doi:10.1172/JCI34523 [Go to this article.]

Figure 2
Aire^GW/+ mice (mixed C57BL/6-129 background) develop spontaneous autoimmune disease that is thymus dependent. (A) Representative H&E-stained sections of lacrimal (top row) and salivary glands (bottom row) in Aire^+/+ (left column) and Aire^GW/+ (right column) mice at 20 weeks of age. Arrows indicate areas of lymphocytic infiltration seen in Aire^GW/+ mice. Images were taken at ×20 magnification. (B) Infiltration scores for lacrimal gland in bone marrow chimeras aged 10 weeks after bone marrow transplantation. The genotypes of the bone marrow recipients (either Aire^+/+ or Aire^GW/+) and donors (either Aire^+/+ or Aire^GW/+) are shown for each cohort. Bars represent average infiltrate score for each group. *P < 0.003 between Aire^+/+ recipients and Aire^GW/+ recipients. Each circle represents an individual mouse. (C) Infiltration scores for salivary gland of thymic transplants into nude C57BL/6 mice aged 12 weeks after transplantation. The genotypes of thymic donors (either Aire^+/+ or Aire^GW/+) are shown. Bars represent average infiltrate score for each group. *P = 0.016 between Aire^+/+ and Aire^GW/+ thymic donors. Each circle represents an individual mouse.