A calculated response: control of inflammation by the innate immune system
J. Clin. Invest. Gregory M. Barton, et al. 118:413 doi:10.1172/JCI34431 [Go to this article.]

Figure 2
Cross-talk between TLR and NLR pathways. The TLR and NLR families sense microbial ligands in different compartments within the cell. NLRs are activated by the presence of cytosolic microbes or the action of microbial virulence mechanisms. These signals feed back on the TLR transcriptional response by activating IL-1R, which activates many of the same signaling pathways as TLRs.