CD133 expression is not restricted to stem cells, and both CD133⁺ and CD133^– metastatic colon cancer cells initiate tumors
J. Clin. Invest. Sergey V. Shmelkov, et al. 118:2111 doi:10.1172/JCI34401 [Go to this article.]

Figure 4
CD133 is expressed in differentiated epithelium of normal human colon. (A and B) Immunostaining with CD133 (AC133) antibody (red) demonstrates the luminal localization (indicated with the arrows) of CD133 in normal human colon. (C and D) Coimmunofluorescence with CD133 (AC133) antibody (red) and EpCAM (a marker of epithelial cells) antibody (green) shows wide distribution of CD133 expression on differentiated epithelium in normal human colon, demonstrating consistency with the murine model. C shows a transverse section of the crypt. D shows a saggital section of the crypt. Scale bar: 50 μm.