Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria
J. Clin. Invest. Angel L. Pey, et al. 118:2858 doi:10.1172/JCI34355 [Go to this article.]

Figure 1
Four hit compounds found to stabilize PAH in the HTS and further detailed fluorescence analyses. (A) Representative thermal denaturation profiles of WT-PAH in the absence (black) or presence of 100 μM of the hit compounds I (red), II (green), III (light blue), and IV (dark blue), resulting from the HTS procedure as monitored by ANS fluorescence. (B) Chemical structures of compounds I, II, III, and IV.