Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
J. Clin. Invest. Hiraku Ono, et al. 118:2959 doi:10.1172/JCI34277 [
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Figure 7Hypothalamic overexpression of CA-S6K leads to insulin resistance under hyperinsulinemic-euglycemic clamp conditions. (
A) Glucose infusion rate required to maintain euglycemia during the clamp period. (
B) Glucose production during basal and clamp periods. (
C) Clamp/basal HGP suppression ratio. (
D) Peripheral glucose uptake during the clamp period. (
E) Phosphoserine IRS-1 and (
F) phosphoserine S6 at the end of the clamp study. Graphs show the ratio of phosphoproteins to total proteins. *
P < 0.05 versus LacZ. **
P < 0.01.
