Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy
J. Clin. Invest. Daniel Cruz, et al. 118:2917 doi:10.1172/JCI34189 [
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Figure 2Comparative domain profiling between leprosy lesions and mycobacterial genomes. Top: Number of mycobacterial genes containing functional lipase domains similar to those of the human genes upregulated in L-lep lesion transcriptome. The PFAM domain containing the lipase activity is shown in parentheses. Middle: Phospholipase C genes were absent in
M. leprae, but induced in the L-lep transcriptome. Bottom: Number of mycobacterial genes containing selected domains involved in phospholipid biosynthesis. Gene names are listed in parentheses for each domain.
