Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice
J. Clin. Invest. Tianfu Li, et al. 118:571 doi:10.1172/JCI33737 [
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Figure 4Electrographic seizure patterns recorded after intraamygdaloid injection of KA. Representative traces show type I (baseline), type II (ictal fast activity), type III (high-voltage spikes of <1 Hz frequency superimposed over type II activity), and type IV (high-voltage, polyspike paroxysmal discharges of >1 Hz frequency) electrographic activity recorded from 3 cortical electrodes after the injection of 0.3 μg KA into the basolateral amygdala of WT mice,
fb-Adk-def mice,
fb-Adk-def mice pretreated with 1 mg/kg DPCPX, and
Adk-Tg mice. Note the aggravation of type IV seizures in
Adk-Tg mice and the lack of type IV seizures in
fb-Adk-def mice. Each trace represents 20 s of recording time.
