Building bone to reverse osteoporosis and repair fractures
J. Clin. Invest. Sundeep Khosla, et al. 118:421 doi:10.1172/JCI33612 [Go to this article.]

Figure 2
The central role of canonical Wnt signaling in regulating osteoblast lineage specification, expansion, and terminal differentiation. Osteoblasts are derived from multipotent mesodermal or neural crest progenitors. Activation of the canonical (ca) Wnt signaling pathway, manifest through β-catenin stabilization, prevents the formation of cartilage (chondrogenesis). Wnt10b prevents adipogenesis (40). The canonical Wnt signaling pathway promotes survival of all cells of the osteoblast lineage and induces the proliferation of preosteoblasts. +, canonical Wnt signaling promotes the process; –, canonical Wnt signaling inhibits the process; AP, alkaline phosphatase; Cola1, collagen α1; DMP1, dentin matrix protein 1; OCN, osteocalcin; Osx, osterix; PTHR, receptor for PTH.