Breast cancer: origins and evolution
J. Clin. Invest. Kornelia Polyak, et al. 117:3155 doi:10.1172/JCI33295 [Go to this article.]

Figure 1
Hypothetical models explaining breast tumor subtypes. Cell of origin (A) and tumor subtype–specific transforming event (B) models. Based on the cell of origin hypothesis, each tumor subtype is initiated in a different cell type (presumably stem or progenitor cell), whereas according to the model depicted in B, the cell of origin can be the same for different tumor subtypes and the tumor phenotype is primarily determined by acquired genetic and epigenetic events.