Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
J. Clin. Invest. Tomohiro Watanabe, et al. 118:545 doi:10.1172/JCI33145 [Go to this article.]

Figure 1
Systemic administration of MDP prevents the development of TNBS colitis. C57BL/10 mice were administered MDP or PBS (i.p.; see Methods) on days –3, –2, and –1 and then challenged with intrarectal TNBS on day 0. (A) Changes in body weight in mice treated with PBS or MDP (n = 10) and challenged with intrarectal administration of TNBS. **P < 0.01 compared with mice treated with PBS. (B) H&E-stained colonic tissue of mice harvested on day 4. Histology of PBS-treated mice showed massive infiltration of mononuclear cells as well as destruction of crypt architecture (top row); histology of MDP-treated mice showed almost normal colonic tissue with minimal infiltration of mononuclear cells (bottom row). Original magnification, ×100. (C) Histology score of the colonic tissue of the mice harvested on day 4.