Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice
J. Clin. Invest. Siddhartha Mukherjee, et al. 118:491 doi:10.1172/JCI33102 [
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Figure 3Osx-positive Op cells do not respond to Bzb, while Osx-negative MSCs respond to Bzb in vitro. Ops were recovered from the compact bone of
Osx-GFP mice by isolation of CD45
–GFP
+ cells. CD45
–GFP
+ Ops plated in vitro showed no change in collagen I clusters, while CD45
–GFP
– MSCs isolated from the same mice showed an increase (arrows). *
P < 0.05;
n = 4. Original magnification, ×100.
