MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets
J. Clin. Invest. Eva van Rooij, et al. 117:2369 doi:10.1172/JCI33099 [
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Figure 3Roles of specific miRNAs in cardiac hypertrophy. Stress signals drive a pathological remodeling response of the adult heart, which is characterized by hypertrophy, ventricular dilatation, and fibrosis. miR-208 is required for stress-dependent remodeling and miR-195, which is induced by cardiac stress, is sufficient to drive cardiac remodeling. miR-133 appears to play a negative role in cardiac hypertrophy (
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