Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia
J. Clin. Invest. Baozhi Yuan, et al. 118:722 doi:10.1172/JCI32702 [
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Figure 7Serum phosphatonin levels in normal,
hyp-,
OC-Cre-PhexΔflox/y, and
Cre-PhexΔflox/y mice.
ELISA measurements of serum FGF-23, MEPE, and sFRP-4 levels demonstrated that all 3 phosphatonins were increased in
hyp- and
Cre-PhexΔflox/y mice. However, serum FGF-23, but not MEPE or sFRP-4, was increased in
OC-Cre-PhexΔflox/y mice. **
P < 0.01, ***
P < 0.001 compared with corresponding normal mice.
