Bone marrow–derived circulating progenitor cells fail to transdifferentiate into adipocytes in adult adipose tissues in mice
J. Clin. Invest. Young Jun Koh, et al. 117:3684 doi:10.1172/JCI32504 [Go to this article.]

Figure 1
No GFP⁺perilipin⁺ adipocytes were detected in the adipose tissues of mice fed a normal diet. Adipose tissues were harvested from C57BL/6J mice that had received BMT from GFP⁺ mice 2 months previously and then fed a normal diet for the 2-month period. Tissues were whole-mounted, coimmunostained for perilipin (adipocytes; red stain) and PECAM-1 or CD11b (blood vessels or macrophages, respectively; blue stain), and merged. No GFP⁺ cells (green stain) were perilipin⁺ adipocytes in the adipose tissues; approximately half of the GFP⁺ cells were CD11b⁺ macrophages in the adipose tissues. Scale bars: 100 μm.