CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice
J. Clin. Invest. Xiuwei Tang, et al. 117:3753 doi:10.1172/JCI32481 [Go to this article.]

Figure 3
Chemopreventive effects of CP-31398 on UVB-induced skin photocarcinogenesis. (A) Drawing showing experimental protocol design. Topical CP-31398 reduces UVB-induced cutaneous tumor growth in terms of tumor number (lower left panel) and tumor size (lower right panel). (B) Picture of representative mice showing effects of CP-31398 on UVB-induced skin tumor development. (C) Expression of cyclins B1, D1, and A in UVB-induced skin tumors of SKH-1 mice following CP-31398 treatment. Treatment protocol and other experimental details are provided in Methods. P values represent significance when compared with vehicle-treated control at corresponding time points.