Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent
J. Clin. Invest. Benyue Zhang, et al. 117:3029 doi:10.1172/JCI32426 [Go to this article.]

Figure 8
TNF-α and T cell deletion. (A) Serum TNF-α levels were determined in LCMV-infected anti-CD137–injected (solid line) or rat IgG–injected (dotted line) mice (n = 5) by ELISA. (B) The frequencies of GP33-41 tetramer–positive splenic CD8⁺ T cells in LCMV Armstrong–infected C57BL/6 TNFα^–/– mice were determined by FACS on day 8 P.I. in mice that had been injected on day 1 P.I. with 200 μg of either rat IgG or anti-CD137. (C) Frequencies of IFN-γ⁺ splenic CD8⁺ T cells from TNFα^–/– mice were determined by FACS on day 8 P.I. in mice that had been injected on day 1 P.I. with 200 μg rat IgG or anti-CD137. Lines indicate the mean.