Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent
J. Clin. Invest. Benyue Zhang, et al. 117:3029 doi:10.1172/JCI32426 [
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Figure 4Anti-CD137–injected LCMV-infected mice remain persistently viremic. Groups of C57BL/6 mice (
n = 5) were infected with LCMV Armstrong and given anti-CD137 mAbs on either day 1 or day 3 P.I. Sera were collected (coll.) on day 8 and day 100 P.I., and plaque assays were performed to detect viable virus. Chronic viral infections, included for comparison to anti-CD137–treated mice, were initiated by injecting 2 × 10
6 PFU LCMV clone 13 i.v. into mice that had also received 500 μg GK1.5 (anti-CD4) 1 day before infection. Sera from chronically infected mice were collected on day 30 P.I. The limit of detection for this assay was 500 PFU/ml.
