Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice
J. Clin. Invest. Danielle C. Shing, et al. 117:3696 doi:10.1172/JCI32390 [
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Figure 4sPRDM16 overexpression in lin
– cells grown in methylcellulose and in LTC-IC.
(
A) Morphology of lin
– cells grown in the presence of cytokines EPO, IL-3, and SCF (MGG stain). (
B) Morphology of lin
– cells after long-term culture in LTC-IC. (
C and
D) CFUs (micrographs,
C; number,
D) of transduced lin
– cells plated 5 weeks after LTC-IC. Original magnification, ×400.
