Ang II–stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice
J. Clin. Invest. Meizi Jiang, et al. 118:2733 doi:10.1172/JCI32381 [
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Figure 5Intimal thickening after cuff placement in response to Ang II infusion in
Lr11–/– mice.
(
A) I/M ratios of femoral arteries in
Lr11+/+ or
Lr11–/– mice after cuff placement with saline or Ang II infusion (1 μg/kg/min for 28 days) are presented as mean ± SD (
n = 15). *
P < 0.05. (
B) mRNA levels of NMHCII-B and LRP1 in injured arteries. Total RNA isolated from the intima or the media of
Lr11+/+ or
Lr11–/– mice was reverse transcribed into cDNA and subjected to real-time PCR analysis using specific primers for NMHCII-B and LRP1, respectively. The amounts of amplified products are expressed relative to the amounts of β-actin transcript, and the ratio of mRNA expression levels of intima and media are presented as mean ± SD (
n = 3). *
P < 0.05.
