Ang II–stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice
J. Clin. Invest. Meizi Jiang, et al. 118:2733 doi:10.1172/JCI32381 [Go to this article.]

Figure 2
Myosin isoform expression pattern in injured arteries after cuff placement in Lr11^–/– mice. (A) Sections of femoral arteries in Lr11^+/+ or Lr11^–/– mice after cuff placement, subjected to immunohistochemistry using antibodies against SMA or NMHCII-B. Arrowheads indicate the internal elastic layers. Scale bars: 50 μm. (B) mRNA levels of myosin isoforms NMHCII-B and SM1 in arteries after cuff placement in Lr11^+/+ or Lr11^–/– mice. Total RNA isolated from the thickened intima (I) or the media (M) of Lr11^+/+ or Lr11^–/– mice was reverse transcribed to cDNA and subjected to real-time PCR analysis using specific primers for NMHCII-B and SM1, respectively. The amounts of amplified products are expressed relative to the amounts of β-actin transcript. Data are presented as mean ± SD (n = 5). *P < 0.05.